A number of oral medications have been tried to treat Peyronie's disease, but they have not been shown to be effective consistently and are not as effective as surgery.
Penile traction therapy involves stretching the penis with a self-applied mechanical device for a period of time to improve penile length, curvature and deformity.
Depending on the specific device, traction therapy may need to be worn for as little as 30 minutes to as much as three to eight hours a day to achieve benefits. The effectiveness of treatment may also depend on the specific device used.
Traction therapy is recommended in both the early and later phases of Peyronie's disease. It's the only non-surgical treatment shown to improve penile length. Traction therapy may also be used combined with other treatments or after surgery for a better outcome.
Medications injected directly into the penis might reduce curvature and pain associated with Peyronie's disease.
Injectable medication options include:
Collagenase. The only FDA-approved medication for Peyronie's disease is collagenase clostridium histolyticum (Xiaflex). This therapy has been shown to improve curvature and bothersome symptoms associated with Peyronie's disease. The treatment works by breaking down the buildup of collagen that causes penile curvature. Collagenase appears to be more effective when used in conjunction with "modeling," which is forcible bending of the penis in the opposite direction of the bend and "traction," which is applying force to the penis with a wearable device.
Verapamil. This is a drug sometimes used to treat high blood pressure. It appears to disrupt the production of that scar tissue that's present in Peyronie's disease. The drug is well tolerated and may reduce pain, too.
Interferon. This medication appears to disrupt the production of fibrous tissue and help break it down. A placebo-controlled trial showed improvement using this therapy over placebo. Interferon also has been shown to reduce penile pain in men with Peyronie's disease.
If you have one of these treatments, you'll likely receive multiple injections over several months. Injectable medications may also be used in combination with oral medications or traction therapies.